ABOUT THE MEETING
We are pleased to announce the BeSHG/NVHG annual genetics symposium, to be held on 21st and 22nd April 2022 at the Bruges Meeting & Convention Centre (BMCC). This 2-day symposium will be preceded on 20th April 2022 by the Genetics Retreat (previously known as the Rolduc meeting). The 2022 genetics symposium will be organized jointly by the Belgian Society for Human Genetics (BeSHG) and the Dutch Society for Human Genetics (NVHG). We hereby continue a tradition we started in 2016 to have a joint meeting every 3 years. As usual, the NVHG symposium is organized in collaboration with the VKGL, VKGN and NACGG. Please note that neither BeSHG nor NVHG nor Genetics Retreat will organize a separate meeting in 2022. Theme Young researchers Venue Staying overnight in Bruges Abstracts Follow the BeSHG website for the most actual information on the symposium. The final program of the meeting will become available towards the end of March. We hope to meet you all at the 2022 BeSHG and NVHG symposium and Genetics Retreat in April in Bruges. Feel free to forward this mailing to your colleagues. On behalf of the Executive Committees, |
| Local organizing team UZA/UA Centre of Medical Genetics Antwerp E: arvid.suls@uantwerpen.be T: +32 (0) 3 275 9763 |
ABOUT THE MEETING
BeSHG/NVHG Annual Genetics Symposium
We are pleased to announce the BeSHG/NVHG annual genetics symposium, to be held on 21st and 22nd April 2022 at the Bruges Meeting & Convention Centre (BMCC).
This 2-day symposium will be preceded on 20th April 2022 by the Genetics Retreat (previously known as the Rolduc meeting).
The 2022 genetics symposium will be organized jointly by the Belgian Society for Human Genetics (BeSHG) and the Dutch Society for Human Genetics (NVHG). We hereby continue a tradition we started in 2016 to have a joint meeting every 3 years. As usual, the NVHG symposium is organized in collaboration with the VKGL, VKGN and NACGG.
Please note that neither BeSHG nor NVHG nor Genetics Retreat will organize a separate meeting in 2022.
Theme
The theme of the meeting will be ‘New advances and tools towards personalized medicine of genetic disorders’. A field of medical genetics that is evolving fast with emerging genomic technologies.
Young researchers
Together with the organizing committee of the Genetics Retreat, we call upon young researchers (PhD students) to attend both meetings.
Abstracts
Abstracts should be submitted before 15 February 2022 through the BeSHG-website following the published guidelines.
WELCOME
Welcome to the 2021 annual meeting of the Dutch Society of Human Genetics.
Exactly one year ago we thought that our successful first virtual meeting would be a “one-of-a-kind interesting experience”, but unfortunately also this year, we will have to go virtual. However, by now everyone is highly experienced in attending virtual symposia, interacting via chats and staring at a screen for a whole day.
We have composed a diverse (interactive) program focusing on the newest developments in the genetics field with frequent breaks to stretch the legs en interact with the sponsors and potential new collaborators.
We will kick of our meeting with the Sandkuijl lecture. From a historical perspective, every two years, the NVHG selected an outstanding researcher with a proven and substantial track record in the same field of genetics as Lodewijk Sandkuijl to award this prestigious personal prize. From this year onwards, we will honor the philosophy of this award but will select a young talent who contribute significant to the development of methodology in the field of bioinformatics and/or statistical genetics. We are pleased to announce that the Lodewijk Sandkuijl Lecture 2021 will be awarded to Michel Nivard for his excellent work in statistical genetics of complex disorders.
Since translational genetic research is the focus of today’s program we have invited Annemieke Aartsma-Rus, Willeke van Roon-Mom and Clara van Karnebeek to update you on national initiatives for therapy development in rare diseases.
Guillaume Canaud, Tjitske Kleefstra and Erica van den Akker will share their experiences with therapeutic trials.
Ruben Kok, Joyce van Meurs and Terry Vrijenhoek will take you on their journey through the field of (inter)national genome initiatives focusing on the collaborative landscapes for optimized disease diagnosis, therapeutics and prevention. We invite you to participate in the round table discussions by using the chat box.
We have received high quality abstracts for our Hot & Happening session in the afternoon and excellent nominees for the NVHG Young Investigator Award that will be presented in the afternoon session.
We will finish the conference with the keynote lecture of Louis Vermeulen, who will present his exciting new work, recently published in Nature, on the competitive behavior of colorectal cancer stem cells, and the possibilities this may give for preventive therapy.
I would like to thank the sponsors for their essential and generous financial contribution to this meeting. Please contact and meet them during the breaks.
I wish you a very inspiring meeting with many new ideas and opportunities for future collaborations!
Mieke van Haelst
LODEWIJK SANDKUIJL
DR. MICHEL NIVARD
The winner of the Lodewijk Sandkuijl award 2021 is Dr. Michel Nivard, VU University Amsterdam. He will receive this prize during the NVHG Annual Meeting on Friday 17 September, and will give an overview of the research he is conducting. Interested? Register now for the NVHG Annual Meeting 2021.
GALJAARD LECTURE
PROF. CISCA WIJMENGA
The NVHG board is proud to announce that the biannual Galjaard lifetime achievement award 2022 is awarded to prof. dr. Cisca Wijmenga for her international leadership in the field of human genetics. Prof. dr. Wijmenga will give her award lecture at the BeSHG/NVHG joint symposium on 21 April in Bruges, Belgium.
SPEAKERS
PROGRAM
*This is preliminary program (version 05 April 2022)
Thursday 21 April 2022 | |
8:45 | Registration |
9:30 | Welcome and introduction presidents BeSHG and NVHG |
9:45 | PLENARY SESSION 1 (Spatial genomics/transcriptomics) |
Chairs: Ligia Mateiu & Roland Kuiper | |
• Musa Mhlanga (Radboud University) | |
• Mihaela Zavolan (University of Basel) | |
11:15 | Coffee break / Meet the sponsors / poster viewing |
11:45 | Selected oral presentations |
Parallel session 1 (BS+BI) | |
Chairs: Julie Soblet & Lude Franke | |
• Mapping the 3D genome of the human retina and its role in retinal disease – Eva D’haene | |
• Single-cell evaluation of DNA damage in offspring after prenatal exposure to chemotherapy – Ilana Struys | |
• Hybrid Autoencoder with Orthogonal Latent Space for Robust Population Structure Inference – Meng Yuan | |
• Mutational processes in a Dutch cohort of children with Constitutional Mismatch Repair Deficiency – Dilys Weijers | |
Parallel session 2 (CL – novel gene/syndrome) | |
Chairs: Damien Lederer & Mieke van Haelst | |
• An unexpected moonlighting function of GTF3A in anti-herpesviral immunity: a new monogenic cause of herpes simplex encephalitis? – Simon Tavernier | |
• Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy with neurological features due to inactivated arachidonic acid-mediated PPAR𝛾 signaling – Nika Schuermans | |
• Somatic activating PIK3R1 and non-hotspot PIK3CA mutations associated with a newly identified clinical phenotype: Capillary Malformation with Dilated Veins (CMDV) – Martina De Bortoli | |
• MAN2C1, a new gene associated with the development of cortical malformations – Hamide Yildirim | |
• CAMLG-CDG: a novel Congenital Disorder of Glycosylation linked to defective membrane trafficking – Matthew Wilson | |
13:00 | Lunch break / Meet the sponsors / poster viewing |
14:00 | Selected oral presentation |
Parallel session 3 (CL – NIPT) | |
Chairs: Kathelijn Keymolen & Erik Sistermans | |
• A cross-country comparison of women’s perspectives on non-invasive prenatal testing in Belgium and the Netherlands – Karuna van der Meij | |
• The presence of viral DNA in a cohort of 108,349 Dutch NIPT samples and its relation to characteristics in pregnancy and cell-free DNA biology – Jasper Linthorst | |
• Multicentric longitudinal performance monitoring of different non-invasive prenatal screening technologies used in Belgium – Armelle Duquenne | |
• Noninvasive Prenatal Test results indicative of maternal malignancies: A nationwide genetic and clinical follow-up study – Catharina Heesterbeek | |
Parallel session 4 (Methodology) | |
Chairs: Nisha Limaye & Gijs van Santen | |
• Generic genome sequencing: one lab flow for all – Gaby Schobers | |
• GENType: all-in-one preimplantation genetic testing by pedigree haplotyping and copy number profiling suitable for third-party reproduction – Machteld Baetens | |
• The Dutch Center for RNA Therapeutics: a center to develop antisense oligonucleotide therapies for patients with nano-rare mutations – Marlen Lauffer | |
• Analysis of the genomewide BAF profiles of selected SNPs allows reliable aneuploidy detection in preimplantation embryos, independent of haplotyping – Pieter Verdyck | |
15:15 | Coffee break / Meet the sponsors / poster viewing |
15:40 | PLENARY SESSION 2 (1+M Genomes) |
Chairs: Gert Matthijs & Johan den Dunnen | |
• Introduction to project – Ruben Kok | |
• Plan of action ‘Belgium’ – Frederik Coppens | |
• Plan of action ‘The Netherlands’ – André Uitterlinden | |
• Genome Estonia – Andres Metspalu, University of Tartu | |
Debate | |
Moderators: Wendy van Zelst-Stams & Elfride De Baere | |
17:15 | NVHG Galjaard lecture |
Chair: Mieke van Haelst | |
19:00 | Gala Dinner and Party |
Friday 22 April 2022 | |
8:45 | Registration |
9:15 | PLENARY SESSION 3 (Polygenic risk scores) |
Chairs: Bert Callewaert & André Uitterlinden | |
• Prof. Peter Devilee (Leiden UMC) | |
• Dr. Rens Reeskamp (Amsterdam UMC) | |
10:45 | General assembly (BeSHG / NVHG) |
11:15 | Coffee break / Meet the sponsors / poster viewing |
11:45 | Selected oral presentations |
Parallel session 5 (BS – animal work) | |
Chairs: Frank Kooy & Terry Vrijenhoek | |
• A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract – Tamara Jarayseh | |
• Single-cell transcriptional dynamics and in vivo enhancer assays provide insight into gene regulatory networks of PRDM13 and IRX1 implicated in North Carolina macular dystrophy – Munevver Burcu Cicekdal | |
• SRSF1 haploinsufficiency is responsible for a new syndromic form of developmental delay including marfanoid habitus with intellectual disability – Elke Bogaert | |
• Live mouse tracker reveals autistic symptoms in the Fmr1 KO mouse model – Mathijs van der Lei | |
• A novel neurodevelopmental syndrome caused by loss-of-function of the Zinc Finger Homeobox 3 (ZFHX3) gene – María del Rocío Pérez Baca | |
Parallel session 6 (CL – diagnostics) | |
Chairs: Saskia Bulk & Aimee Paulussen | |
• Routine transcriptome sequencing improves diagnosis for neurodevelopmental disorders by identifying pathogenic effects of non-coding, putatively benign and missed variants – Jordy Dekker | |
• Overview of cancer predisposition syndromes in a national, unselected cohort of 836 children with a neoplasm – Jette Bakhuizen | |
• Polygenic risk scores predict overweight and obesity in the Dutch population – Bahar Sedaghati-khayat | |
• The potential of 3D facial analysis to recognize monogenic autism in the spectrum – Yoeri Sleyp | |
13:00 | Lunch break / Meet the sponsors / poster viewing |
14:00 | PLENARY SESSION 4 (VUS) |
Chairs: Lut Van Laer & Lisenka Vissers | |
• Prof. Roddy Walsh (Amsterdam UMC) | |
• Prof. Rosa Rademakers (University of Antwerpen) | |
15:30 | Coffee break / Meet the sponsors / poster viewing |
16:00 | Surprise act |
Chair: Gert Matthijs | |
17:00 | Closing remarks and best poster / oral presentation awards |
17:30 | Reception |
Thursday 21 April 2022 | |
08:45-09:30 | Registration |
09:30-09:45 | Welcome and introduction presidents BeSHG and NVHG |
09:45-11:15 | PLENARY SESSION 1 (Spatial genomics/transcriptomics) |
Chairs: Ligia Mateiu & Roland Kuiper | |
• Musa Mhlanga (Radboud University) | |
• Mihaela Zavolan (University of Basel) | |
11:15-11:45 | Coffee break / Meet the sponsors / poster viewing |
11:45-13:00 | Selected oral presentations |
Parallel session 1 (BS+BI) | |
Chairs: Julie Soblet & Lude Franke | |
• Mapping the 3D genome of the human retina and its role in retinal disease – Eva D’haene | |
• Single-cell evaluation of DNA damage in offspring after prenatal exposure to chemotherapy – Ilana Struys | |
• Hybrid Autoencoder with Orthogonal Latent Space for Robust Population Structure Inference – Meng Yuan | |
• Mutational processes in a Dutch cohort of children with Constitutional Mismatch Repair Deficiency – Dilys Weijers | |
Parallel session 2 (CL – novel gene/syndrome) | |
Chairs: Damien Lederer & Mieke van Haelst | |
• An unexpected moonlighting function of GTF3A in anti-herpesviral immunity: a new monogenic cause of herpes simplex encephalitis? – Simon Tavernier | |
• Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy with neurological features due to inactivated arachidonic acid-mediated PPAR𝛾 signaling – Nika Schuermans | |
• Somatic activating PIK3R1 and non-hotspot PIK3CA mutations associated with a newly identified clinical phenotype: Capillary Malformation with Dilated Veins (CMDV) – Martina De Bortoli | |
• MAN2C1, a new gene associated with the development of cortical malformations – Hamide Yildirim | |
• CAMLG-CDG: a novel Congenital Disorder of Glycosylation linked to defective membrane trafficking – Matthew Wilson | |
13:00-14:00 | Lunch break / Meet the sponsors / poster viewing |
14:00-15:15 | Selected oral presentation |
Parallel session 3 (CL – NIPT) | |
Chairs: Kathelijn Keymolen & Erik Sistermans | |
• A cross-country comparison of women’s perspectives on non-invasive prenatal testing in Belgium and the Netherlands – Karuna van der Meij | |
• The presence of viral DNA in a cohort of 108,349 Dutch NIPT samples and its relation to characteristics in pregnancy and cell-free DNA biology – Jasper Linthorst | |
• Multicentric longitudinal performance monitoring of different non-invasive prenatal screening technologies used in Belgium – Armelle Duquenne | |
• Noninvasive Prenatal Test results indicative of maternal malignancies: A nationwide genetic and clinical follow-up study – Catharina Heesterbeek | |
Parallel session 4 (Methodology) | |
Chairs: Nisha Limaye & Gijs van Santen | |
• Generic genome sequencing: one lab flow for all – Gaby Schobers | |
• GENType: all-in-one preimplantation genetic testing by pedigree haplotyping and copy number profiling suitable for third-party reproduction – Machteld Baetens | |
• The Dutch Center for RNA Therapeutics: a center to develop antisense oligonucleotide therapies for patients with nano-rare mutations – Marlen Lauffer | |
• Analysis of the genomewide BAF profiles of selected SNPs allows reliable aneuploidy detection in preimplantation embryos, independent of haplotyping – Pieter Verdyck | |
15:15-15:40 | Coffee break / Meet the sponsors / poster viewing |
15:40-17:15 | PLENARY SESSION 2 (1+M Genomes) |
Chairs: Gert Matthijs & Johan den Dunnen | |
• Introduction to project – Ruben Kok | |
• Plan of action ‘Belgium’ – Frederik Coppens | |
• Plan of action ‘The Netherlands’ – André Uitterlinden | |
• Genome Estonia – Andres Metspalu, University of Tartu | |
Debate | |
Moderators: Wendy van Zelst-Stams & Elfride De Baere | |
17:15-18:00 | NVHG Galjaard lecture |
Chair: Mieke van Haelst | |
19:00-00:00 | Gala Dinner and Party |
Friday 22 April 2022 | |
08:45-09:15 | Registration |
09:15-10:45 | PLENARY SESSION 3 (Polygenic risk scores) |
Chairs: Bert Callewaert & André Uitterlinden | |
• Prof. Peter Devilee (Leiden UMC) | |
• Dr. Rens Reeskamp (Amsterdam UMC) | |
10:45-11:15 | General assembly (BeSHG / NVHG) |
11:15-11:45 | Coffee break / Meet the sponsors / poster viewing |
11:45-13:00 | Selected oral presentations |
Parallel session 5 (BS – animal work) | |
Chairs: Frank Kooy & Terry Vrijenhoek | |
• A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract – Tamara Jarayseh | |
• Single-cell transcriptional dynamics and in vivo enhancer assays provide insight into gene regulatory networks of PRDM13 and IRX1 implicated in North Carolina macular dystrophy – Munevver Burcu Cicekdal | |
• SRSF1 haploinsufficiency is responsible for a new syndromic form of developmental delay including marfanoid habitus with intellectual disability – Elke Bogaert | |
• Live mouse tracker reveals autistic symptoms in the Fmr1 KO mouse model – Mathijs van der Lei | |
• A novel neurodevelopmental syndrome caused by loss-of-function of the Zinc Finger Homeobox 3 (ZFHX3) gene – María del Rocío Pérez Baca | |
Parallel session 6 (CL – diagnostics) | |
Chairs: Saskia Bulk & Aimee Paulussen | |
• Routine transcriptome sequencing improves diagnosis for neurodevelopmental disorders by identifying pathogenic effects of non-coding, putatively benign and missed variants – Jordy Dekker | |
• Overview of cancer predisposition syndromes in a national, unselected cohort of 836 children with a neoplasm – Jette Bakhuizen | |
• Polygenic risk scores predict overweight and obesity in the Dutch population – Bahar Sedaghati-khayat | |
• The potential of 3D facial analysis to recognize monogenic autism in the spectrum – Yoeri Sleyp | |
13:00-14:00 | Lunch break / Meet the sponsors / poster viewing |
14:00-15:30 | PLENARY SESSION 4 (VUS) |
Chairs: Lut Van Laer & Lisenka Vissers | |
• Prof. Roddy Walsh (Amsterdam UMC) | |
• Prof. Rosa Rademakers (University of Antwerpen) | |
15:30-16:00 | Coffee break / Meet the sponsors / poster viewing |
16:00-17:00 | Surprise act |
Chair: Gert Matthijs | |
17:00-17:30 | Closing remarks and best poster / oral presentation awards |
17:30 | Reception |
SPONSORS
We express our gratitude to all our sponsors for their continued support.
The Young Investigator Award will be awarded to a promising young, talented, early-career scientist, who defended his/her dissertation between 01 of August 2021 and 01 April 2022.
Registration deadline is 8 of April
GENERAL INFORMATION
REGISTRATION INFORMATION
For meeting registration and abstract submission, go to ‘My BeSHG‘: https://www.beshg.be/my-beshg
Early-bird registration: 21th of February 2022 (after this date registration prize will increase with 50€!)
Submission deadline abstracts: 15th of February 2022
VENUE
BMCC is a brand new, modern convention center (opening January 2022) in the heart of historic Bruges, which offers a unique experience.
STAYING OVERNIGHT IN BRUGES
Looking for an inexpensive hotel to stay overnight? Do not wait too long to book a room, Bruges is a very popular city.
Please check our suggestions:
- Radisson Blu Brugge**** https://www.visitbrugesconventionbureau.be/nl/hotel-radisson-blu
- Le Bois de Bruges**** https://www.visitbrugesconventionbureau.be/nl/le-bois-de-bruges
- Hotel Portinari**** https://www.visitbrugesconventionbureau.be/nl/hotel-portinari-nl
- Martin’s Brugge*** https://www.visitbrugesconventionbureau.be/nl/martins-brugge-nl
- Ibis Budget Centrum Station* –https://www.visitbrugesconventionbureau.be/nl/ibis-budget-brugge-centrum-station-previously-etap
In case we have the switch our live meeting to an online meeting due to COVID-regulations, we will organize the meeting in 2023 again in Bruges. Therefore, it is very important you ask whether you can rebook your hotelroom to next year, if necessary!
Registration for the Meeting is OPEN!
When registering for the conference, you will have to agree to the General Terms & Conditions for participants.
NVHG collects and uses your personal information to:
– facilitate registration for the event
– send you a confirmation e-mail
– send you a personal link to participate in the event
– send you a survey after the event
– show your name in the online platform
– collect viewing statistics
Your data will be shared with Invitado, our online event platform partner, to create personal login credentials.
Invitado will deleted these data within 30 days after the event.
One fee for all participants
-
All live sessions
-
On-demand sessions
CANCELLATIONS AND REFUNDS
Notice of cancellation must be made in writing by e-mail to the Meeting organisers: henny.schurmann@mumc.nl
Registration fees may be refunded if written cancellation has been received as follows:
- until Sep 10, 2020: full refund
- from Sep 11, 2020: 50% refund
The cancellation will not be effective until a written acknowledgement from the NVHG organisers is received. In the case of over-payment or double payment, refund requests must be made in writing and sent to the meeting organisers by e-mail. No refunds will be granted for unattended events or early termination of attendance, in case of cancellation of speakers or any other incidents during the conference, which are beyond the control of the conference organisers.
No exceptions to the refund policy can be made, including health or family issues. By registering to the NVHG Annual Meeting 2020, participants agree that the organising committee does not assume any liability whatsoever.
ACCESS TO THE VIRTUAL PLATFORM
Participants will receive by email the instructions to access the platform once registered.
CERTIFICATES
Certificates of attendance will be sent to all participants electronically after the meeting when attendance is confirmed in the online platform.
ACCREDITATION
Accreditation will be given only when participants request it at the registration and when the attendance is confirmed by logging in to the meeting.
BIG number and full name should be provided at registration.
LANGUAGE
The official language of the meeting will be English. No simultaneous translation will be provided.
Follow the BeSHG website for the most actual information on the symposium. The final program of the meeting will become available towards the end of March.
We hope to meet you all at the 2022 BeSHG and NVHG symposium and Genetics Retreat in April in Bruges. Feel free to forward this mailing to your colleagues.
On behalf of the Executive Committees,
Dr. Arvid Suls (Local organizer)
Prof. dr. Gert Matthijs (President BeSHG)
Dr. Mieke van Haelst (President NVHG)
Dr. Willem Voncken and dr. Alex Hoischen on behalf of the organizing committee of the Genetics Retreat
Local organizing team
UZA/UA Centre of Medical Genetics Antwerp
E: arvid.suls@uantwerpen.be
T: +32 (0) 3 275 9763
